From October 18 to 19, 2025, the 2025 Poultry Nutrition and Health Forum was held in Beijing. Gendone specially invited Researcher Haijun Zhang from the Institute of Feed Research of the Chinese Academy of Agricultural Sciences (CAAS) to present a report titled “Effects of Guanidinoacetic Acid Impurities on Chick Hatching Performance and Growth Development” The presentation shared the latest research findings from Dr. Zhang’s team on the target animal safety of guanidinoacetic acid (GAA) product impurities and the safety limits for three types of impurities in GAA products, providing the industry with data-driven insights and theoretical references for standardized production processes, animal health protection, and food safety assurance.

In his report, Dr. Zhang highlighted that his team studied the potential residues of cyanamide, as well as possible polymeric by-products dicyandiamide and melamine, in the GAA production process. They conducted experimental research on embryos and broiler chicks to evaluate the effects of GAA impurities on chick hatchability, early growth, and liver and kidney health; and the dose-response effects of GAA product impurity combinations on broiler growth and development.

The results indicated that the median lethal dose (LD50) of cyanamide injected into eggs is approximately 7.5 mg per egg, dicyandiamide is 60 mg per egg, and melamine is 20 mg per egg. Exceeding these impurity levels causes a sharp increase in embryonic mortality. In feed, cyanamide levels above 300 mg/t (equivalent to 500 mg/kg in GAA) or dicyandiamide above 600 mg/t (equivalent to 1000 mg/kg in GAA) result in a drastic decline in broiler growth performance.

Gendone tested market-sourced GAA samples for content and key impurity indicators, performing quantitative analyses according to the company standard “Feed Additive — Guanidinoacetic Acid” (Standard No. Q/GAJTN 002-2025). Results showed that all market samples contained multiple impurities exceeding the standard limits, posing significant risks to animal health and food safety.

As the original developer of GAA and the only domestic company in China with full GAA intellectual property rights, Gendone leverages its mature research foundation and advanced technical capabilities to implement the world’s strictest quality control standards, rigorously controlling GAA impurities to safeguard feed and livestock safety.

On the afternoon of October 19, Dr. Libin Yang, President of Gendone, attended the forum’s interactive session on “Cost Reduction, Efficiency Improvement, and Product Quality.” The session was hosted by Caimei Shao, Vice President of Wellhope Foods Co., who guided panelists to share insights and experiences from their respective companies.

During the forum, Dr. Yang shared that, from a raw material perspective, Gendone had measured and calculated the nutritional value of GAA for livestock and poultry. One kilogram of GAA provides nutritional energy and protein equivalent to 26 kg of corn, 12 kg of soybean meal, and 5 kg of soybean oil. Going forward, Gendone will continue to collaborate with Dr. Haijun Zhang’s team at CAAS to measure the metabolizable energy of GAA in poultry, providing more precise solutions for cost reduction and efficiency improvement in poultry production.

Looking ahead, Gendone will continue to focus on animal nutrition, lead the development of GAA safety standards and precision applications, and introduce more scientifically validated, high-efficiency solutions into the poultry industry to help drive high-quality growth and new milestones in China’s poultry sector.